Nebulized Pentamidine-Induced Acute Renal Allograft Dysfunction

Nebulized Pentamidine-Induced Acute Renal Allograft Dysfunction

Acute kidney injury (AKI) is a recognised complication of intravenous pentamidine therapy. A direct nephrotoxic effect leading to acute tubular necrosis has been postulated. We report a case of severe renal allograft dysfunction due to nebulised pentamidine. The patient presented with repeated episodes of AKI without obvious cause and acute tubular necrosis only on renal histology. Nebulised pe...

Chronic renal allograft dysfunction.

The major causes of renal transplant loss are death from vascular, malignant or infectious disease, and loss of the allograft from chronic renal dysfunction associated with the development of graft fibrosis and glomerulosclerosis. Chronic allograft nephropathy (CAN) is the histologic description of the fibrosis, vascular and glomerular damage occurring in renal allografts. Clinical programs rel...

Acute allograft pancreatitis associated with renal allograft rejection.

Acute allograft pancreatitis is common following simultaneous pancreas and kidney (SPK) transplantation with either bladder or enteric drainage w1,2x. Allograft pancreatitis may be caused by infection, bladder drainage problems, alcohol, drugs and diet w1x. Pancreatic allograft rejection, usually occurring in the context of renal allograft rejection, may cause a syndrome similar to acute allogr...

Combination Therapy with Losartan and α-Tocopherol in Acute Ureteral Obstruction-Induced Renal Excretory Dysfunction and Acidification Defect

Background: Previous study by the authors showed that a-tocopherol prevents oxidative stress but would not improve depressed excretory variables in post-obstructed kidney (POK) after release of 24-h unilateral ureteral obstruction (UUO). This study is a supplementary investigation on the effects of a-tocopherol combined with an antagonist of angiotensin-II type-1 (AT1) receptor on renal dysfunc...

Prevention of Acute Renal Allograft Injury